Polishing in Viral Vector Vaccine Process
Sartorius offers solutions for contaminant removal that are designed to deliver better results in less time, from development to manufacturing scale. Our team works with you to co-develop solutions to get to market faster.
Polishing at a Glance
Process Development of the Polishing Step by Membrane Chromatography
Sartobind® membrane adsorbers are chromatographic membranes utilized to efficiently remove contaminants such as DNA and host cell proteins. Sartobind® offers a number of benefits compared to conventional column chromatography such as easy handling, high flow and high capacities for large molecules. Sartobind® ligands can be evaluated in small scalable format (96 well plates, Sartobind® Pico, Sartobind Nano®) for process development. You can use our MODDE® Design of Experiments software solutions to achieve outstanding results in no time.
Polishing at Pilot and Manufacturing Scale
Sartobind® membrane technology allows you to shift from slow and oversized expensive columns to small, single-use capsules. You can save up to 70% processing time and work space with ready-to-use membrane chromatography. The design of Sartobind® capsule, features optimized flow channels, significantly reducing void volume, sharpening breakthrough curves and reducing elution volumes. And as viral vector processes grow in size, a range of new cassette format accommodates the necessary process scale. Contained capsules and sterile gamma irradiated cassettes enable purification of viral vectors that cannot be sterile filtered.